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MicroRNA Expression is Down-Regulated and Reorganized in Prefrontal Cortex of Depressed Suicide Subjects

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Smallheiser, N. R., Lugli, G., Hooriyah, S. R., Torvik, V. I., Turecki, G., & Dwivedi, Y. (2012). MicroRNA Expression is Down-Regulated and Reorganized in Prefrontal Cortex of Depressed Suicide Subjects. PLoS ONE, 7(3), e33201. doi:10.1371/journal.pone.0033201

Publication Abstract

Recent studies suggest that alterations in expression of genes, including those which regulate neural and structural plasticity, may be crucial in the pathogenesis of depression. MicroRNAs (miRNAs) are newly discovered regulators of gene expression that have recently been implicated in a variety of human diseases, including neuropsychiatric diseases.

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